yrammuS 要概101Supareak PRASERTHDAM102Jittima LUCKANAGULDevelopment of public catalytic materials database constructed via techniques in quantum chemistry, artificial intelligence, and high-throughput experimentation to enhance environmental friendliness and sustainability of gas and coal-fired stationary power plants in Thailand (Project 2022)Development of targetable virus-like particles for the delivery of biological macromolecules for immunotherapy(Project 2022)75(TOC), liquid chromatography high resolution mass spectrometry (LCHRMS) and fluorescence excitation – emission matrix spectroscopy (F-EEM). Sampling was performed in dry and wet seasons at medium-scale water treatment plant that employs rapid sand filter in Central Thailand. Influent total manganese (total Mn), existing in particulate and dissolved forms, ranges from 200 to 230 µg/L at dissolved oxygen levels of 1.3–3.8 mg/L. Scanning electron microscopy shows the surface coverage of top sand grains by metal oxides since a year of the operation. The 16S rRNA gene sequence analysis shows abundance of bacteria that are capable of oxidizing Mn (i.e. Dechloromonas and Hyphomicrobium) on the sand surface. The manganese oxidation potential using the inductively coupled plasma (ICP) method indicates that Bacillus megaterium BL4 shows the highest Mn removal. Manganese oxidizing bacteria prefers to work as a community. LCHRMS identifies two distinct groups of molecular formulae between the inlet and backwash water from sand filtration system. The ratio of total nitrogen over TOC was greater for backwash water than influent water, suggesting production of protein-like compounds preferential removal of carbon-rich organic matter by sand filter. Under this condition, the system can remove >90% of total Mn, with a residual Mn of 20 – 30 µg/L.This project aims to support the sustainable production of electricity in Thailand, depending greatly on coal and natural gas as primary feedstocks, while also promoting environmentally-friendly chemical and petrochemical industries via the reduction of harmful gases: carbon monoxide, nitrogen oxide, carbon dioxide, and unburnt hydrocarbons via the catalytic process utilizing three-way catalysts (TWC) with CO2 reduction catalysts (CO2RR). Thus, this work constructs the public materials database containing physical, chemical, and mechanical properties of high-entropy alloys (HEA) that will be maintained and further developed by our research group at Chulalongkorn University, the Japan Advanced Institute of Science and Technology (JAIST), and the University of Tokyo (UTokyo), Japan. Ultimately, we aim to expand this public database’s use and future development to academic and industrial sectors to enhance the production of chemical and petrochemical products and innovations concerning metals and alloys to help the nation escape from being the middle-income trap countries.Antibody conjugation of virus-like particles (VLPs) is achieved by introducing an azide group onto the surface of the VLP, allowing a covalent bond with molecules containing cyclic alkynes through a click reaction. HIV-1 Gag proteins are used to form VLP. In mammalian host cells, VLPs have previously induced the expression of azide by unnatural azide sugar, and VLPs can recover the characteristics of the host cell lipid membrane, including the azide matrix. The physical properties of the azide VLPs and their cell inputs are similar to those of native particles. Azide VLPs were combined with anti-CD3 antibodies and the target delivery to CD3+ cells was evaluated. Increased particle absorption of CD3+ cells and reduced internalization of CD3- cells can be observed, suggesting the feasibility of VLPs modified with azide for antibody decoration and application as target delivery systems.Rep. Grant. Res., Asahi Glass Foundation (2023)
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